کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2598551 1562631 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Comparison of the lethal effects of chemical warfare nerve agents across multiple ages
ترجمه فارسی عنوان
مقایسه اثرات مرگبار عامل عصب شیمیایی در طول چندین سال
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


• Children may be more vulnerable than adults to chemical warfare nerve agents (CWNA).
• We estimated the 24 h LD50 for seven CWNA in rats at six times in development.
• Perinatal and adult rats were more susceptible than pubertal rats to the G-agents.
• Age-related differences were not observed in rats for the V-agents.

Children may be inherently more vulnerable than adults to the lethal effects associated with chemical warfare nerve agent (CWNA) exposure because of their closer proximity to the ground, smaller body mass, higher respiratory rate, increased skin permeability and immature metabolic systems. Unfortunately, there have only been a handful of studies on the effects of CWNA in pediatric animal models, and more research is needed to confirm this hypothesis. Using a stagewise, adaptive dose design, we estimated the 24 h median lethal dose for subcutaneous exposure to seven CWNA in both male and female Sprague-Dawley rats at six different developmental times. Perinatal (postnatal day [PND] 7, 14 and 21) and adult (PND 70) rats were more susceptible than pubertal (PND 28 and 42) rats to the lethal effects associated with exposure to tabun, sarin, soman and cyclosarin. Age-related differences in susceptibility were not observed in rats exposed to VM, Russian VX or VX.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 241, 22 January 2016, Pages 167–174
نویسندگان
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