کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2599622 1133221 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration
چکیده انگلیسی

Cannabidiol (CBD), a major non-psychotropic constituent of fiber-type cannabis plant, has been reported to possess diverse biological activities, including anti-proliferative effect on cancer cells. Although CBD is obtained from non-enzymatic decarboxylation of its parent molecule, cannabidiolic acid (CBDA), few studies have investigated whether CBDA itself is biologically active. Results of the current investigation revealed that CBDA inhibits migration of the highly invasive MDA-MB-231 human breast cancer cells, apparently through a mechanism involving inhibition of cAMP-dependent protein kinase A, coupled with an activation of the small GTPase, RhoA. It is established that activation of the RhoA signaling pathway leads to inhibition of the mobility of various cancer cells, including MDA-MB-231 cells. The data presented in this report suggest for the first time that as an active component in the cannabis plant, CBDA offers potential therapeutic modality in the abrogation of cancer cell migration, including aggressive breast cancers.


► Cannabidiolic acid (CBDA) exists as a major component in the fiber-type cannabis.
► CBDA is identified as an “active component”.
► CBDA is an inhibitor of highly aggressive human breast cancer cell migration.
► The mechanism responsible for the effects of CBDA involves activation of RhoA.
► RhoA is an inhibitor of cancer cell mobility.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 214, Issue 3, 15 November 2012, Pages 314–319
نویسندگان
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