کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2600061 1133250 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ga(III) complexes—The effect of metal coordination on potential systemic absorption after topical exposure
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Ga(III) complexes—The effect of metal coordination on potential systemic absorption after topical exposure
چکیده انگلیسی

The handling of elemental gallium is not thought to be harmful, but this assumption does not consider metal coordination which readily occurs in physiological fluids. The aim of this work was to determine Ga(III) coordination behaviour in simple solutions and assess the effects of complex formation upon skin permeation in vitro. Ga(III) coordination was modelled using metal–ligand stability constants in silico and the permeation of the metal through human and porcine skin determined using four test conditions. Ga(III) was presented to the skin as: (1) Ga3+ ions; (2) a −ve citrate complex (Ganeg); (3) a mixture of +ve and −ve complexes (Gamix) and (4) a mixture of +ve hydroxide complexes (Gapos). The permeability coefficient (Kp) of Ga(III) through human skin increased by almost 2 orders of magnitude when applied as free Ga3+ ions or a Ganeg complex (the two most water soluble complexes), compared to Gamix or Gapos. This trend was not well modelled by porcine skin which proved to be less of a barrier to Ga(III) permeation compared to human skin (Kp = 2 × 10−3 ± 2 × 10−4 cm h−1). Given the significant transdermal bioavailablity of Ga(III) demonstrated by this study, it would appear prudent to re-evaluate the dermal toxicity of this metal.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 202, Issue 3, 10 May 2011, Pages 155–160
نویسندگان
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