کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2600560 1133272 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Scorpion toxins that block transient currents (IA) of rat cerebellum granular cells
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Scorpion toxins that block transient currents (IA) of rat cerebellum granular cells
چکیده انگلیسی

This communication is a revision of the state-of-the-art knowledge of the field of scorpion toxins specific for the K+-channels, responsible for the IA currents of granular cells of rat cerebellum, maintained in vitro culture. There are 6 members of the sub-family α-KTx15 known to affect the IA currents. They are: toxins Aa1 from Androctonus australis Garzoni, BmTx3 from Buthusmartensi Karch, AmmTx3 from Androctonus mauretanicus mauretanicus, AaTx1 and AaTx2 from A. australis Garzoni and Discrepin from Tityus discrepans. They share high sequence similarity, apart from Discrepin, which causes an irreversible effect on the IA currents and is the most thoroughly studied toxin of the sub-family α-KTx15. The three-dimensional structure of Discrepin was determined and a series of mutants were synthesized and assayed in the system with the aim of identifying possible amino acids or sequence segments responsible for the irreversible effect found. In this revision some unpublished original data are also included to foster future work on the field, as well as a short discussion on some relevant aspects still pending and possible limitations associated with the strategy proposed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 187, Issue 1, 22 May 2009, Pages 1–9
نویسندگان
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