کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2601188 1133305 2009 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Use of toxicogenomics to understand mechanisms of drug-induced hepatotoxicity during drug discovery and development
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Use of toxicogenomics to understand mechanisms of drug-induced hepatotoxicity during drug discovery and development
چکیده انگلیسی

Hepatotoxicity is a common cause of failure in drug discovery and development and is also frequently the source of adverse drug reactions. Therefore, a better prediction, characterization and understanding of drug-induced hepatotoxicity could result in safer drugs and a more efficient drug discovery and development process. Among the ‘omics technologies, toxicogenomics (or the use of gene expression profiling in toxicology) represents an attractive approach to predict toxicity and to gain a mechanistic understanding of toxic changes. In this review, we illustrate, using selected examples, how toxicogenomics can be applied to investigate drug-induced hepatotoxicity in animal models and in vitro systems. In general, this technology can not only improve the discipline of toxicology and risk assessment but also represent an extremely effective, hypothesis-generating alternative to rapidly understand mechanisms of hepatotoxicity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 186, Issue 1, 10 April 2009, Pages 22–31
نویسندگان
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