کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2601437 1133320 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biological monitoring of low benzene exposure in Italian traffic policemen
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Biological monitoring of low benzene exposure in Italian traffic policemen
چکیده انگلیسی

A comparative evaluation of urinary biomarkers was carried out to characterize benzene exposure in a group of 100 traffic policemen of the city of Parma (Italy). All subjects were monitored once, in two consecutive days characterized by similar climatic conditions but preceded by two windy days. Benzene ambient concentration measured by municipal air monitoring stations was 1 μg/m3 (Day 1) and 2 μg/m3 (Day 2). Personal exposure to ambient concentrations of benzene, toluene, ethylbenzene and xylene (BTEX) was assessed by using Radiello® passive-diffusive samplers in a subgroup of 24 workers. Benzene metabolites, t,t-muconic acid (t,t-MA) and S-phenylmercapturic acid (S-PMA) were determined by isotopic dilution liquid chromatography–tandem mass spectrometry on spot urine samples collected at the end of the shift. Urinary benzene (U-B) was determined by solid-phase microextraction gas chromatography–mass spectrometry. Airborne benzene concentration expressed as median [and interquartile range] was 6.07 [0.28–9.53] μg/m3, as assessed by personal sampling. Urinary concentrations of biomarkers in the whole group were 41.8 [34.1–89.8] μg/g creatinine for t,t-MA, 0.67 [0.23–1.32] μg/g creatinine for S-PMA, and 0.16 [0.13–0.26] μg/l for U-B. Smokers eliminated significantly higher concentrations of unchanged BTEX and benzene metabolites than non-smokers (p < 0.05). When traffic policemen were distinguished into indoor (n = 31) and outdoor workers, no significant differences were observed for either airborne benzene or urinary biomarkers. Significantly lower concentrations of S-PMA and U-B were determined in samples collected at Day 1 as compared to Day 2 (p < 0.0001 and p = 0.003, respectively) suggesting that these biomarkers are enough sensitive and specific to detect changes in airborne benzene concentration even at few μg/m3.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 181, Issue 1, 10 September 2008, Pages 25–30
نویسندگان
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