کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2601787 1133342 2008 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of in utero and lactational exposure to endosulfan in prefrontal cortex of male rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Effects of in utero and lactational exposure to endosulfan in prefrontal cortex of male rats
چکیده انگلیسی

The possible neurotoxic effects of the organochlorine pesticide endosulfan have been evaluated on male offspring rats exposed in utero and during lactation. Dams were treated with 0.61 mg or 6.12 mg endosulfan/(kg day) from the gestation beginning until the weaning. Male offspring rats were sacrificed at post-natal days (PND) 15, 30 and 60, and possible alterations in the content and metabolism of biogenic amines and amino acids were determined in prefrontal cortex using high-performance liquid chromatography (HPLC). Globally, endosulfan induced an increase in amino acid content in prefrontal cortex at PND 15 and PND 30. However, the levels of GABA at PND 15 and those of glutamine at PND 30 were not modified. At PND 60, a significant reduction in the content of GABA and taurine was observed, while the concentration of glutamate, aspartate and glutamine remained constant. Endosulfan did not modify norepinephrine and dopamine content, but serotonin concentration was increased at PND 30 and PND 60 and serotoninergic and dopaminergic metabolism was also modified. These results suggest that pre- and post-natal exposure to endosulfan affects biogenic amines and amino acids in prefrontal cortex, and those variations could be related to several alterations in the functions in which the prefrontal cortex is involved.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 176, Issue 1, 4 January 2008, Pages 58–67
نویسندگان
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