کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2602996 1133803 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Toxicity of nanoparticles of ZnO, CuO and TiO2 to yeast Saccharomyces cerevisiae
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Toxicity of nanoparticles of ZnO, CuO and TiO2 to yeast Saccharomyces cerevisiae
چکیده انگلیسی

The aim of this study was to evaluate the toxic effect of nanosized ZnO, CuO and TiO2 to Saccharomyces cerevisiae – a widely used unicellular eukaryotic model organisms in molecular and cell biology. The effect of metal oxide nanoparticles, their bulk forms and respective ionic forms were compared. The bioavailable Zn2+ and Cu2+ ions in the growth medium were quantified by recombinant microbial sensors.Nano and bulk TiO2 were not toxic even at 20000 mg/l. Both, nano and bulk ZnO were of comparable toxicity (8-h EC50 121–134 mg ZnO/l and 24-h EC50 131–158 mg/l). The toxicity was explained by soluble Zn-ions as proved by the microbial sensor. However, nano CuO was about 60-fold more toxic than bulk CuO: 8-h EC50 were 20.7 and 1297 mg CuO/l and 24-h EC50 were 13.4 and 873 mg/l, respectively. The increase in toxicity of both CuO formulations at 24th hour of growth was due to the increased dissolution of copper ions from CuO over time. Comparison of EC50 values of nano CuO, bulk CuO and Cu2+ with bioavailable copper concentrations in the growth medium showed that the solubilized Cu-ions explained only about 50% of the toxicity of both, nano and bulk CuO. To our knowledge, this is the first study that evaluates the toxicity of ZnO, CuO and TiO2 nanoparticles to S.cerevisiae.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology in Vitro - Volume 23, Issue 6, September 2009, Pages 1116–1122
نویسندگان
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