کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2603337 1133817 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bifenthrin-induced oxidative stress in human erythrocytes in vitro and protective effect of selected flavonols
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Bifenthrin-induced oxidative stress in human erythrocytes in vitro and protective effect of selected flavonols
چکیده انگلیسی

Bifenthrin is a synthetic pyrethroid with a broad spectrum of insecticidal and acaricidal activity used to control wide range of insect pests in a variety of applications. This investigation was designed to examine (1) bifenthrin as an inducer of oxidative stress in human erythrocytes in vitro through effects on catalase (CAT) and superoxide dismutase (SOD) activities, and (2) the role of the flavonoids quercetin (Q, 40 and 80 μM) and rutin (R, 80 μM) in alleviating the effects of bifenthrin.Erythrocytes were divided into portions. The first portion was incubated for 4 h at 37 °C with different concentrations (0, 42.2, 211, 1055 ppm) of bifenthrin. The other portions were preincubated with Q or R for 30 min, followed incubation with bifenthrin for 4 h. The influence of solvent (ethanol) was also checked on the parameters studied. Malondialdehyde (MDA) concentrations, CAT and SOD activities were measured in all treatment portions of erythrocytes.Our results demonstrated that bifenthrin-induced oxidative stress causes enhanced lipid peroxidation and decreased antioxidative enzyme activities in human peripheral blood. R pretreated erythrocytes were protected against the increase of MDA induced by bifenthrin. Q (80 μM) and R pretreated erythrocytes were protected against the inhibition of CAT activity induced by bifenthrin.The protective action against the inhibition of SOD activity of Q was greater than that of R at the same concentration. These results suggest that Q and R may play a role in reducing bifenthrin-induced oxidative stress in vitro.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology in Vitro - Volume 24, Issue 2, March 2010, Pages 460–464
نویسندگان
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