کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
26746 | 43974 | 2012 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Ultraviolet-photoproduct of acetaminophen: Structure determination and evaluation of ecotoxicological effect Ultraviolet-photoproduct of acetaminophen: Structure determination and evaluation of ecotoxicological effect](/preview/png/26746.png)
This study was focused on photodegradation of acetaminophen (AA) exposed to ultraviolet (UV) irradiation at 254 nm delivered by a system similar to that used for sterilization in sewage treatment plants. The degradation of AA during irradiation for up to 96 h was monitored by means of high-performance liquid chromatography (HPLC). Based on the mass/charge ratio (m/z) of the protonated ion and the mass fragmentation pattern in electrospray ionization time-of-flight mass spectrometry (ESI-TOF/MS/MS), the photoproduct was identified as 1-(2-amino-5-hydroxyphenyl)ethanone (1). Examination of toxicity by means of a luminescent bacteria test (ISO11348) indicated that AA solution was nontoxic, whereas photo-exposed AA solution was toxic (EC50: 29.46 mg/L). The toxicity of synthetic compound 1 was shown to account for a substantial part of the toxicity of photo-exposed AA. These results indicate the importance of investigating not only parent compounds, but also photoproducts the risk assessment of pharmaceuticals in aquatic environments.
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► Photodegradation of acetaminophen and the generation of its photoproduct by UV irradiation were examined.
► The photoproduct was 1-(2-amino-5-hydroxyphenyl)ethanone.
► Acetaminophen solution had no effect on aquatic organisms.
► Photo-exposed acetaminophen solution showed marked toxicity for aquatic organisms.
► Synthetic 1-(2-amino-5-hydroxyphenyl)ethanone showed toxicity stronger than acetaminophen solution.
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 249, 1 December 2012, Pages 29–35