کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2784958 | 1153917 | 2011 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Cellular senescence: putting the paradoxes in perspective Cellular senescence: putting the paradoxes in perspective](/preview/png/2784958.png)
Cellular senescence arrests the proliferation of potential cancer cells, and so is a potent tumor suppressive mechanism, akin to apoptosis. Or is it? Why did cells evolve an anti-cancer mechanism that arrests, rather than kills, would-be tumor cells? Recent discoveries that senescent cells secrete growth factors, proteases and cytokines provide a shifting view—from senescence as a cell autonomous suppressor of tumorigenesis to senescence as a means to mobilize the systemic and local tissue milieu for repair. In some instances, this mobilization benefits the organism, but in others it can be detrimental. These discoveries provide potential mechanisms by which cellular senescence might contribute to the diverse, and seemingly incongruent, processes of tumor suppression, tumor promotion, tissue repair, and aging.
Journal: Current Opinion in Genetics & Development - Volume 21, Issue 1, February 2011, Pages 107–112