کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2784968 | 1153921 | 2011 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: RNA structure and the mechanisms of alternative splicing RNA structure and the mechanisms of alternative splicing](/preview/png/2784968.png)
Alternative splicing is a widespread means of increasing protein diversity and regulating gene expression in eukaryotes. Much progress has been made in understanding the proteins involved in regulating alternative splicing, the sequences they bind to, and how these interactions lead to changes in splicing patterns. However, several recent studies have identified other players involved in regulating alternative splicing. A major theme emerging from these studies is that RNA secondary structures play an under appreciated role in the regulation of alternative splicing. This review provides an overview of the basic aspects of splicing regulation and highlights recent progress in understanding the role of RNA secondary structure in this process.
► Alternative splicing is an important mechanism of increasing protein diversity and regulating gene expression.
► We highlight the basic principles of the mechanisms of alternative splicing.
► We discuss recent advances in understanding the role of RNA structure in the regulation of alternative splicing.
Journal: Current Opinion in Genetics & Development - Volume 21, Issue 4, August 2011, Pages 373–379