کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2784970 | 1153921 | 2011 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Alternative splicing takes shape during neuronal development Alternative splicing takes shape during neuronal development](/preview/png/2784970.png)
The spatial and temporal control of alternative splicing is a major mechanism used to generate proteomic diversity in the brain. Microarray and Next Generation Sequencing approaches reveal mechanistic insights about networks of tissue-specific RNA binding proteins and micro RNAs that coordinate suites of alternative splicing patterns during neuronal differentiation. In the context of large-scale changes, one alternative splicing switch during embryonic brain development is crucial for neuronal migration and the laminar organization of the cerebral cortex. A major challenge to understand alternative splicing at the systems level is now being approached by the design of integrative modeling approaches that predict the combinatorial control of brain-specific exons.
► Splicing factor – micro RNA networks coordinate the process of neuronal differentiation.
► Computational modeling with Bayesian networks predicts the combinatorial control of splicing.
► Nova2 induces exon skipping in the Disabled-1 transcript to orchestrate neuronal migration.
Journal: Current Opinion in Genetics & Development - Volume 21, Issue 4, August 2011, Pages 388–394