کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2785024 | 1153925 | 2009 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Transposable elements in gene regulation and in the evolution of vertebrate genomes Transposable elements in gene regulation and in the evolution of vertebrate genomes](/preview/png/2785024.png)
Repetitive DNA and in particular transposable elements have been intimately linked to eukaryotic genomes for millions of years. Once overlooked for being only a collection of selfish debris and a nuisance for sequence assembly, genomic repeats are now being recognized as a key driving force in genome evolution. Indeed, by changing the DNA landscape of genomes, transposable elements have been a rich source of innovation in genes, regulatory elements and genome structures. In this review, I will focus on recent advances that demonstrate that genomic repeats have had a global impact on vertebrate gene regulatory networks. I will also summarize results that show how transposable elements have been a major catalyst of structural rearrangements throughout evolution.
Journal: Current Opinion in Genetics & Development - Volume 19, Issue 6, December 2009, Pages 607–612