کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2785125 | 1153930 | 2008 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: NF-κB and cancer — identifying targets and mechanisms NF-κB and cancer — identifying targets and mechanisms](/preview/png/2785125.png)
A connection between inflammation and carcinogenesis has long been known, but the precise mechanisms are just beginning to be understood. NF-κB proteins, transcription factors which integrate stress signals and orchestrate immune responses, have also recently been linked to carcinogenesis. Hallmarks of cancer development include self-sufficiency in growth signals, insensitivity to growth-inhibitors, evasion of apoptosis, limitless replicative potential, tissue invasion and metastasis, and sustained angiogenesis. NF-κB signaling has been implicated in each of these hallmarks, and recent experimental studies have illuminated the mechanistic pathways by which NF-κB signaling contributes to these aspects of carcinogenesis. This review will focus on recent experimental data supporting the hypothesis that inflammation promotes carcinogenesis, and that NF-κB signaling is at the heart of such inflammation.
Journal: Current Opinion in Genetics & Development - Volume 18, Issue 1, February 2008, Pages 19–26