کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2785130 | 1153930 | 2008 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Brick by brick: metabolism and tumor cell growth Brick by brick: metabolism and tumor cell growth](/preview/png/2785130.png)
Tumor cells display increased metabolic autonomy in comparison to non-transformed cells, taking up nutrients and metabolizing them in pathways that support growth and proliferation. Classical work in tumor cell metabolism focused on bioenergetics, particularly enhanced glycolysis and suppressed oxidative phosphorylation (the ‘Warburg effect’). But the biosynthetic activities required to create daughter cells are equally important for tumor growth, and recent studies are now bringing these pathways into focus. In this review, we discuss how tumor cells achieve high rates of nucleotide and fatty acid synthesis, how oncogenes and tumor suppressors influence these activities, and how glutamine metabolism enables macromolecular synthesis in proliferating cells.
Journal: Current Opinion in Genetics & Development - Volume 18, Issue 1, February 2008, Pages 54–61