کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2785145 | 1153931 | 2009 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Temporal dynamics of patterning by morphogen gradients Temporal dynamics of patterning by morphogen gradients](/preview/png/2785145.png)
Morphogens act as graded positional cues to control cell fate specification in many developing tissues. This concept, in which a signaling gradient regulates differential gene expression in a concentration-dependent manner, has received considerable experimental support. Nevertheless, several recent studies have challenged the straightforward model of morphogen activity. In particular, the observation that pattern formation is a dynamic process has raised questions about the influence of time on morphogen activity. Here we propose that the spatiotemporal dynamics of the cellular response to a morphogen gradient depend on a combination of temporal alterations to the morphogen gradient itself, the dynamics of its signal transduction and downstream interactions between target genes.
Journal: Current Opinion in Genetics & Development - Volume 19, Issue 4, August 2009, Pages 315–322