کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2785188 1153934 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
New functions for an old variant: no substitute for histone H3.3
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
New functions for an old variant: no substitute for histone H3.3
چکیده انگلیسی

Histone proteins often come in different variants serving specialized functions in addition to their fundamental role in packaging DNA. The metazoan histone H3.3 has been most closely associated with active transcription. Its role in histone replacement at active genes and promoters is conserved to the single histone H3 in yeast. However, recent genetic studies in flies have challenged its importance as a mark of active chromatin, and revealed unexpected insights into essential functions of H3.3 in the germline. With strikingly little amino acid sequence difference to the canonical H3, H3.3 therefore accomplishes a surprising variety of cellular and developmental processes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Genetics & Development - Volume 20, Issue 2, April 2010, Pages 110–117
نویسندگان
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