کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2785355 | 1153942 | 2006 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Regulation of higher-order chromatin structures by nucleosome-remodelling factors Regulation of higher-order chromatin structures by nucleosome-remodelling factors](/preview/png/2785355.png)
Nucleosome-remodelling factors are key facilitators of chromatin dynamics. At the level of single nucleosomes, they are involved in nucleosome-repositioning, altering histone–DNA interactions, disassembly of nucleosomes, and the exchange of histones with variants of different properties. The fundamental nature of chromatin dictates that nucleosome-remodelling affects all aspects of eukaryotic DNA metabolism, but much less is known about the functional interactions of nucleosome-remodelling factors with folded chromatin fibres. Because remodelling machines are abundant constituents of eukaryotic nuclei and, therefore, have ample potential to interact with chromatin, they might also affect higher-order chromatin architecture. Recent observations support roles for nucleosome-remodelling factors at the supra-nucleosomal level.
Journal: Current Opinion in Genetics & Development - Volume 16, Issue 2, April 2006, Pages 151–156