کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2785357 | 1153942 | 2006 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Developmental mechanisms and cis-regulatory codes Developmental mechanisms and cis-regulatory codes](/preview/png/2785357.png)
Complex networks of transcriptional interactions control the processes of animal development. These networks begin with broad positional information that patterns the cells of the early embryo, and end with precise expression profiles that provide the functions of fully differentiated cells. At the heart of these networks are cis-regulatory modules (CRMs), which contain binding sites for regulatory proteins and control the spatial and temporal expression of genes within the network. Recent studies in several model systems have begun to decipher the ‘cis-regulatory codes’ of CRMs involved in various developmental processes. These studies suggest that CRMs involved in regulating co-expressed genes share sequence characteristics that can be identified by in silico approaches. They also suggest that CRMs involved in specific types of developmental events have common binding site architectures, which can be linked to their specific functions.
Journal: Current Opinion in Genetics & Development - Volume 16, Issue 2, April 2006, Pages 165–170