کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2785384 | 1153945 | 2006 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The sequences of the human sex chromosomes The sequences of the human sex chromosomes](/preview/png/2785384.png)
The sequences of both of the human sex chromosomes and of a substantial part of the chimpanzee Y chromosome have now been determined, and most of the protein-coding genes have been identified. The X chromosome codes for more than 800 proteins but the Y chromosome for only ∼60, illustrating their very different evolutionary histories since their origin from an autosomal pair ∼300 million years ago and explaining their differential importance in disease. These sequences have provided the basis for understanding normal patterns of variation, such as the distribution of SNPs, and patterns of linkage disequilibrium. In addition, they have been useful for identifying variants associated with simple Mendelian disorders such as microphthalmia or mental retardation, and more complex disorders such as osteoporosis.
Journal: Current Opinion in Genetics & Development - Volume 16, Issue 3, June 2006, Pages 213–218