کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2785386 | 1153945 | 2006 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The human Y chromosome: a masculine chromosome The human Y chromosome: a masculine chromosome](/preview/png/2785386.png)
Once considered to be a genetic wasteland of no scientific interest beyond sex determination, the human Y chromosome has made a significant comeback in the past few decades and is currently implicated in multiple diseases, including spermatogenic failure — absent or very low levels of sperm production. The Y chromosome contains over one hundred testis-specific transcripts, and several deletions have been described that remove some of these transcripts, thereby causing spermatogenic failure. Screening for such deletions in infertile men is now a standard part of clinical evaluation. Many other Y-chromosome structural variants, some of which affect gene copy number, have been reported recently, and future research will be necessary to address the phenotypic effect of these structural variants.
Journal: Current Opinion in Genetics & Development - Volume 16, Issue 3, June 2006, Pages 225–232