کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2785396 | 1153945 | 2006 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: X-linked premature ovarian failure: a complex disease X-linked premature ovarian failure: a complex disease](/preview/png/2785396.png)
Involvement of the X chromosome in premature ovarian failure was demonstrated by the relatively frequent chromosomal rearrangements in patients, but the requirement of two X chromosomes for ovarian function was quite unexplained until recently. Review of the data on chromosomal rearrangements suggests that several genes along the X chromosomes contribute to ovarian function. In most instances, no single X chromosome gene has a causative role in premature ovarian failure, and the phenotype is likely to derive from the additive effect of X-linked and non-X-linked factors. Recent data on a small group of balanced X–autosome translocations showed that X-linked premature ovarian failure might also be caused by a different mechanism, namely position effect of the X chromosome on non-X-linked genes, and suggest a peculiar organization of the X chromosome during oogenesis.
Journal: Current Opinion in Genetics & Development - Volume 16, Issue 3, June 2006, Pages 293–300