کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2785442 | 1153951 | 2008 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The long and the short of Wnt signaling in C. elegans The long and the short of Wnt signaling in C. elegans](/preview/png/2785442.png)
The simplicity of C. elegans makes it an outstanding system to study the role of Wnt signaling in development. Many asymmetric cell divisions in C. elegans require the Wnt/β-catenin asymmetry pathway. Recent studies confirm that SYS-1 is a structurally and functionally divergent β-catenin, and implicate lipids and retrograde trafficking in maintenance of WRM-1/β-catenin asymmetry. Wnts also regulate short-range events such as spindle rotation and gastrulation, and a PCP-like pathway regulates asymmetric divisions. Long-range, cell non-autonomous Wnt signals regulate vulval induction. Both short-range and long-range Wnt signals are regulated by recycling of MIG-14/Wntless via the retromer complex. These studies indicate that C. elegans continues to be useful for identifying new, conserved mechanisms underlying Wnt signaling in metazoans.
Journal: Current Opinion in Genetics & Development - Volume 18, Issue 4, August 2008, Pages 362–367