کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2785500 1153958 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Balancing cell adhesion and Wnt signaling, the key role of β-catenin
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Balancing cell adhesion and Wnt signaling, the key role of β-catenin
چکیده انگلیسی

Controlled regulation of cell proliferation and differentiation is essential for embryonic development and requires the coordinated regulation of cell–cell adhesion and gene transcription. The armadillo repeat protein β-catenin is an important integrator of both processes. β-catenin acts in the Wnt signaling pathway, activating the transcription of crucial target genes responsible for cellular proliferation and differentiation. β-catenin also controls E-cadherin-mediated cell adhesion at the plasma membrane and mediates the interplay of adherens junction molecules with the actin cytoskeleton. Both functions of β-catenin are de-regulated in human malignancies, thereby leading both to the loss of cell–cell adhesion and to the increased transcription of Wnt target genes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Genetics & Development - Volume 16, Issue 1, February 2006, Pages 51–59
نویسندگان
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