کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2796757 1568806 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association of hyperglycemia mediated increased advanced glycation and erythrocyte antioxidant enzyme activity in different stages of diabetic retinopathy
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Association of hyperglycemia mediated increased advanced glycation and erythrocyte antioxidant enzyme activity in different stages of diabetic retinopathy
چکیده انگلیسی

AimThis study aimed to evaluate whether hyperglycemia mediated increased formation of advanced glycation end products (AGEs) was associated with erythrocyte antioxidant enzyme activity in subjects with different stages of diabetic retinopathy (DR).MethodsSerum level of AGEs was determined by enzyme linked immunosorbent assay. Erythrocyte superoxide dismutase (SOD), glutathione reductase (GR) and catalase activity were estimated by enzymatic reaction based spectrophotometric assay in patients with type 2 diabetes with proliferative diabetic retinopathy (PDR), non-proliferative diabetic retinopathy (NPDR) and no retinopathy (DNR) and also in healthy non-diabetic controls (HC).ResultErythrocyte SOD and GR activity was significantly lower among NPDR (p = 0.024, 0.0017, respectively) and PDR (p = 0.0003, 0.0001, respectively) subjects compared with DNR individuals. A significant inverse correlation was observed between serum AGEs and erythrocyte SOD or GR activity in DNR (p = 0.0019; r = −0.3033, p = 0.0021; r = −0.3015, respectively), NPDR (p = 0.0001; r = −0.4602, p = 0.0003; r = −0.4161, respectively), and PDR (p < 0.0001; r = −0.6753, p < 0.0001; r = −0.5854, respectively) individuals.ConclusionPoor glycemia may be the key factor enhancing AGE formation, which may be associated with lower erythrocyte SOD and GR activity along with increased catalase activity in DR.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diabetes Research and Clinical Practice - Volume 100, Issue 3, June 2013, Pages 376–384
نویسندگان
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