کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2797217 1155638 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Can procalcitonin predict bone infection in people with diabetes with infected foot ulcers? A pilot study
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Can procalcitonin predict bone infection in people with diabetes with infected foot ulcers? A pilot study
چکیده انگلیسی

AimsThe diagnosis of osteomyelitis is a key step of diabetic foot management. Previous studies showed that procalcitonin (PCT), a novel infection marker, is superior to conventional infection markers in the diagnosis of diabetic foot infection. This study aimed to investigate the serum levels of PCT and other conventional infection markers in diabetic persons with and without osteomyelitis.MethodsTwenty-four patients (18 male, mean age: 61.9 ± 10.8 years) with infected foot ulcers were prospectively enrolled. Clinical characteristics of the wounds were noted. Blood samples were obtained for biochemical analysis. Magnetic resonance imaging of the foot was performed in all patients to diagnose osteomyelitis.ResultsOsteomyelitis was found in 13 of 24 (54%) patients. PCT levels were 66.7 ± 43.5 pg/ml in patients with osteomyelitis and 58.6 ± 35.5 pg/ml in patients without osteomyelitis. The difference did not reach statistical significance (p = 0.627). Erythrocyte sedimentation rate, but not C-reactive protein and white blood cell count, was found significantly higher in patients with osteomyelitis.ConclusionIn this group of patients, PCT failed to discriminate patients with bone infection. Erythrocyte sedimentation rate can be used as a marker of osteomyelitis in diabetic persons.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diabetes Research and Clinical Practice - Volume 94, Issue 1, October 2011, Pages 53–56
نویسندگان
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