کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2799301 | 1155966 | 2013 | 15 صفحه PDF | دانلود رایگان |
• Estrogens influence mammalian auditory development.
• Estrogens protect the mammalian auditory system from damage.
• Estrogens enhance auditory function during breeding periods.
• Brain-derived estrogens can enhance local response properties in the avian forebrain.
Sex-steroid hormones are well-known regulators of vocal motor behavior in several organisms. A large body of evidence now indicates that these same hormones modulate processing at multiple levels of the ascending auditory pathway. The goal of this review is to provide a comparative analysis of the role of estrogens in vertebrate auditory function. Four major conclusions can be drawn from the literature: First, estrogens may influence the development of the mammalian auditory system. Second, estrogenic signaling protects the mammalian auditory system from noise- and age-related damage. Third, estrogens optimize auditory processing during periods of reproductive readiness in multiple vertebrate lineages. Finally, brain-derived estrogens can act locally to enhance auditory response properties in at least one avian species. This comparative examination may lead to a better appreciation of the role of estrogens in the processing of natural vocalizations and mayprovide useful insights toward alleviating auditory dysfunctions emanating from hormonal imbalances.
Journal: Frontiers in Neuroendocrinology - Volume 34, Issue 4, October 2013, Pages 285–299