Interactions of the GnRH receptor with heterotrimeric G proteins

G protein-coupled receptors (GPCRs) are the largest class of integral membrane protein receptors in the human genome. We examined here the reports whether the GnRH receptor (GnRHR) interacts with a single or multiple types of G proteins. It seems that the GnRHR, as other GPCRs, alternates between various conformations and is stabilized by its ligands, other modulators and intracellular partners in selective conformations culminating in coupling with a single type or multiple G proteins in a cell- and context-specific manner.

► The nature of the G-protein which interacts with the GnRH receptor is controversial.
► The interacting G-protein will dictate the biological outcome.
► The conformation of the GnRH receptor may dictate the active G-protein.