کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2809249 | 1158028 | 2010 | 8 صفحه PDF | دانلود رایگان |
Strawberries have been reported to be potent antioxidants and reduce cardiovascular risk factors, such as elevated blood pressure, hyperglycemia, dyslipidemia, and inflammation in limited studies. We hypothesized that freeze-dried strawberry supplementation will improve blood pressure, impaired glucose, dyslipidemia, or circulating adhesion molecules in obese subjects with metabolic syndrome, thereby lowering cardiovascular risk factors in these subjects. Twenty-seven subjects with metabolic syndrome (2 males and 25 females; body mass index, 37.5 ± 2.15 kg/m2; age, 47.0 ± 3.0 years [means ± SE]) consumed 4 cups of freeze-dried strawberry beverage (50g freeze-dried strawberries ∼ 3 cups fresh strawberries) or equivalent amounts of fluids (controls, 4 cups of water) daily for 8 weeks in a randomized controlled trial. Anthropometrics and blood pressure measurements, assessment of dietary intakes, and fasting blood draws were conducted at screen and 8 weeks of the study. Strawberry supplementation significantly decreased total and low-density lipoprotein cholesterol (5.8 ± 0.2 to 5.2 ± 0.2 mmol/L and 3.5 ± 0.2 to 3.1 ± 0.1 mmol/L, respectively [means ± SE], P < .05) and small low-density lipoprotein particles using nuclear magnetic resonance–determined lipoprotein subclass profile vs controls at 8 weeks (794.6 ± 94.0 to 681.8 ± 86.0 nmol/L [means ± SE], P < .05). Strawberry supplementation further decreased circulating levels of vascular cell adhesion molecule-1 vs controls at 8 weeks (272.7 ± 17.4 to 223.0 ± 14.0 ng/mL [means ± SE], P < .05). Serum glucose, triglycerides, high-density lipoprotein cholesterol, blood pressure, and waist circumference were not affected. Thus, short-term freeze-dried strawberry supplementation improved selected atherosclerotic risk factors, including dyslipidemia and circulating adhesion molecules in subjects with metabolic syndrome, and these results need confirmation in future trials.
Journal: Nutrition Research - Volume 30, Issue 7, July 2010, Pages 462–469