کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2810419 1158439 2012 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mitochondrial sirtuins: regulators of protein acylation and metabolism
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Mitochondrial sirtuins: regulators of protein acylation and metabolism
چکیده انگلیسی

Sirtuins are NAD+-dependent protein deacetylases and have been implicated in the regulation of metabolism, stress responses, and aging. Three sirtuins are located in mitochondria: SIRT3, 4, and 5. SIRT3 deacetylates and regulates the enzymatic activity of many metabolic enzymes in mitochondria, whereas SIRT5 removes two novel post-translational modifications, lysine malonylation and succinylation. Here, we review the current knowledge of how mitochondrial sirtuins function in metabolism and metabolic diseases, and offer a conceptual model how they may regulate mitochondrial function through distinct deacylation activities (deacetylation, demalonylation, or desuccinylation).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 23, Issue 9, September 2012, Pages 467–476
نویسندگان
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