کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2813429 1159054 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Diagnóstico prenatal y array-CGH II: gestaciones de bajo riesgo
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Diagnóstico prenatal y array-CGH II: gestaciones de bajo riesgo
چکیده انگلیسی
The array-CGH technique has recently been established as a first-tier diagnostic test for studying patients with congenital anomalies, idiopathic mental retardation and other neurological disorders. However, its use in prenatal diagnosis is still being evaluated, especially in low-risk pregnancies. A study was conducted on a population of 530 low-risk pregnancy women using both conventional karyotype and array-CGH for prenatal diagnosis. Whereas conventional karyotype detected 3 foetuses (0.5%) with unbalanced cytogenetic aberrations (one of them was undefined), array-CGH detected 8 foetuses with copy number aberrations (1.5%), and positively identified the undefined cytogenetic aberration detected using karyotype. In conclusion, this study proposes array-CGH as a useful tool in prenatal diagnosis for low-risk pregnancies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diagnóstico Prenatal - Volume 23, Issue 2, April–June 2012, Pages 49-55
نویسندگان
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