کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2813429 | 1159054 | 2012 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Diagnóstico prenatal y array-CGH II: gestaciones de bajo riesgo
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
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چکیده انگلیسی
The array-CGH technique has recently been established as a first-tier diagnostic test for studying patients with congenital anomalies, idiopathic mental retardation and other neurological disorders. However, its use in prenatal diagnosis is still being evaluated, especially in low-risk pregnancies. A study was conducted on a population of 530 low-risk pregnancy women using both conventional karyotype and array-CGH for prenatal diagnosis. Whereas conventional karyotype detected 3 foetuses (0.5%) with unbalanced cytogenetic aberrations (one of them was undefined), array-CGH detected 8 foetuses with copy number aberrations (1.5%), and positively identified the undefined cytogenetic aberration detected using karyotype. In conclusion, this study proposes array-CGH as a useful tool in prenatal diagnosis for low-risk pregnancies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diagnóstico Prenatal - Volume 23, Issue 2, AprilâJune 2012, Pages 49-55
Journal: Diagnóstico Prenatal - Volume 23, Issue 2, AprilâJune 2012, Pages 49-55
نویسندگان
MarÃa Eugenia Querejeta, Beatriz Nieva, Juncal Navajas, Juan Cruz Cigudosa, Javier Suela,