کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2820604 | 1160868 | 2014 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Identification and comparative analysis of G protein-coupled receptors in Pediculus humanus humanus Identification and comparative analysis of G protein-coupled receptors in Pediculus humanus humanus](/preview/png/2820604.png)
• A genome-wide survey revealed 81 GPCRs in P. h. humanus.
• P. h. humanus contains a more complete set of neuropeptide/protein hormone receptors.
• Neuropeptide and protein hormone receptors were less duplicated in P. h. humanus.
• ACP, AVPL, HE6 and Boss receptors were absent in P. h. humanus.
• P. h. humanus has a relative original and concise GPCR regulation system.
The body louse has the smallest genome size among the known genome-sequenced insects. Here, 81 GPCRs were identified in Pediculus humanus humanus, 56, 14, 6 and 5 GPCRs for family-A, -B, -C and -D, respectively. These GPCRs constitute the comparable repertoire of GPCRs with other insects. Moreover, it contains a more complete set of neuropeptide and protein hormone receptors not even than Acyrthosiphon pisum but also Drosophila melanogaster, for example, Sulfakinin, Corazonin, Trissin and PTHRL only presented in P. h. humanus but lost either in A. pisum or D. melanogaster. However, it has less duplication among the sub-families. Meanwhile, ACP, AVPL, HE6 receptors and Boss were also absent from P. h. humanus. These results indicated that the repertoire of GPCRs in P. h. humanus were not affected by its smallest genome size, and further suggested that P. h. humanus has a relatively original and concise GPCR regulation system.
Journal: Genomics - Volume 104, Issue 1, July 2014, Pages 58–67