کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2820660 1160878 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Collective effects of SNPs on transgenerational inheritance in Caenorhabditis elegans and budding yeast
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Collective effects of SNPs on transgenerational inheritance in Caenorhabditis elegans and budding yeast
چکیده انگلیسی


• Yeast segregants with higher MAC showed a more dramatic shortening of the lag phase after ethanol exposure.
• The short lag phase as acquired by ethanol training was more dramatically lost after recovery for the high MAC group.
• There was a preferential association between MAC and traits linked with higher number of additive QTLs.

We studied the collective effects of single nucleotide polymorphisms (SNPs) on transgenerational inheritance in Caenorhabditis elegans recombinant inbred advanced intercross lines (RIAILs) and yeast segregants. We divided the RIAILs and segregants into two groups of high and low minor allele content (MAC). RIAILs with higher MAC needed less generations of benzaldehyde training to gain a stable olfactory imprint and showed a greater change from normal after benzaldehyde training. Yeast segregants with higher MAC showed a more dramatic shortening of the lag phase length after ethanol exposure. The short lag phase as acquired by ethanol training was more dramatically lost after recovery in ethanol free medium for the high MAC group. We also found a preferential association between MAC and traits linked with higher number of additive QTLs. These results suggest a role for the collective effects of SNPs in transgenerational inheritance, and may help explain human variations in disease susceptibility.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Genomics - Volume 106, Issue 1, July 2015, Pages 23–29
نویسندگان
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