کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2820720 | 1160884 | 2015 | 6 صفحه PDF | دانلود رایگان |
• In humans, chimps, gorillas (HCG) pregnancies, embryos embed into maternal tissue.
• Pregnancy implantation genes were tested for selection in the HCG ancestral branch.
• Two immune system genes (HLA-E and KIR2DL4) showed evidence of positive selection.
• The result suggests a role for immunological adaptations in embryo deep invasion.
A major evolutionary change in the lineage ancestral to humans, chimpanzee and gorilla (HCG) has been the embedding of the embryo into maternal tissue. Thus, the first layer of cells (trophoblast) to differentiate after fertilization must adapt to invade the uterus. Such event would likely leave signatures of positive selection at genes with roles in embryo implantation. Here, 163 pregnancy implantation genes are tested for evidence of adaptive diversification in the ancestral lineage to HCG. Two immune system genes, HLA-E and KIR2DL4 showed evidence of positive selection. Some of the positive selected sites involve amino acid substitution with predicted damaging effects on protein function, thus highlighting the possibility of antagonistic pleiotropic effects. Selection at a gene coding for a receptor expressed in uterine cells (KIR) that interacts with trophoblast human leukocyte antigen (HLA) genes suggests a main role for immunological adaptations in embryo deep invasion of the maternal endometrium.
Journal: Genomics - Volume 105, Issue 1, January 2015, Pages 17–22