کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2820777 1160890 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Transcriptome map of mouse isochores in embryonic and neonatal cortex
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Transcriptome map of mouse isochores in embryonic and neonatal cortex
چکیده انگلیسی

Several studies on adult tissues agree on the presence of a positive effect of the genomic and genic base composition on mammalian gene expression. Recent literature supports the idea that during developmental processes GC-poor genomic regions are preferentially implicated. We investigate the relationship between the compositional properties of the isochores and of the genes with their respective expression activity during developmental processes. Using RNA-seq data from two distinct developmental stages of the mouse cortex, embryonic day 18 (E18) and postnatal day 7 (P7), we established for the first time a developmental-related transcriptome map of the mouse isochores. Additionally, for each stage we estimated the correlation between isochores' GC level and their expression activity, and the genes' expression patterns for each isochore family. Our analyses add evidence supporting the idea that during development GC-poor isochores are preferentially implicated, and confirm the positive effect of genes' GC level on their expression activity.


► We report the first transcriptome map of isochores related to developmental stages.
► A preferential implication of the GC-poor isochores during development is proposed.
► We found that genes' expression level increases as GC of the isochores increases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Genomics - Volume 101, Issue 2, February 2013, Pages 120–124
نویسندگان
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