کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2820970 1160911 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identification and Characterization of Human snoRNA Core Promoters
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Identification and Characterization of Human snoRNA Core Promoters
چکیده انگلیسی

Small nucleolar RNAs (snoRNAs) represent one of the largest groups of functional non-protein coding RNAs currently known in eukaryotic cells. The processing of intron encoded snoRNAs has been well documented; however, the transcriptional regulation of snoRNA genes is still poorly understood, most likely due to the lack of characterization of snoRNA promoters. Here we used a computational approach to predict core promoters for 131 human snoRNAs. Majority of putative snoRNA promoters are supported by DNase I hypersensitivities, RNA polymerase II ChIP-seq peaks, or CAGE tag clusters. Based on the genomic organizations of predicted human snoRNA promoters, we propose five transcriptional models of those snoRNA genes; we also found evidence that some intronic human snoRNAs might have their own promoters. The present study is the first in silico screening of human snoRNAs promoters; and we anticipate the data will facilitate further molecular characterization of transcriptional control of human snoRNA genes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Genomics - Volume 96, Issue 1, July 2010, Pages 50–56
نویسندگان
, , , , ,