کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2821055 1160918 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Common copy number variations in fifty radiosensitive cell lines
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Common copy number variations in fifty radiosensitive cell lines
چکیده انگلیسی

Hypersensitivity to radiation exposure is a major challenge to radiotherapy in the treatment of cancer patients. Copy number variations (CNVs) are believed to identify genomic regions of functional significance for radiosensitivity (RS) but have yet to be systematically investigated. We used Affymetrix 6.0 SNP arrays to survey common CNVs in a cohort of 50 radiosensitive lymphoblastoid cell lines (RS-LCLs) derived from patients with undiagnosed diseases. A total of 317 CNVs that were present in at least 10% of the studied cell lines were identified. Three hundred and eight CNVs overlapped with polymorphic CNVs, 13 of which were significantly enriched in the RS-LCLs compared to the reference. The remaining 9 CNVs were novel. The majority of these enriched and novel CNVs were chromosomal gains. The dominance of the chromosomal gains over losses is inconsistent with the traditional concept of molecular basis of RS and suggests more complex genetic mechanisms for RS.


► Copy number variations (CNVs) were investigated in a radiosentive population.
► Chromosomal gains dominated radiosensitivity-associated CNVs.
► Complex genetic mechanisms regulate radiosensitivity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Genomics - Volume 99, Issue 2, February 2012, Pages 96–100
نویسندگان
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