کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2821268 | 1160937 | 2006 | 12 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Genomic profiling of cortical neurons following exposure to β-amyloid Genomic profiling of cortical neurons following exposure to β-amyloid](/preview/png/2821268.png)
In vitro and in vivo studies have shown that β-amyloid peptide induces neuronal cell death. To explore the molecular basis underlying β-amyloid-induced toxicity, we analyzed gene expression profiles of cultured rat cortical neurons treated for 24 and 48 h with synthetic β-amyloid peptide. From the 8740 genes interrogated by oligonucleotide microarray analysis, 241 genes were found to be differentially expressed and segregated into distinct clusters. Functional clustering based on gene ontologies showed coordinated expression of genes with common biological functions and metabolic pathways. The comparison with genes differentially expressed in cerebellar granule neurons following serum and potassium deprivation indicates the existence of common regulatory mechanisms underlying neuronal cell death. Our results offer a genomic view of the changes that accompany β-amyloid-induced neurodegeneration.
Journal: Genomics - Volume 88, Issue 4, October 2006, Pages 468–479