کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2821427 | 1160950 | 2006 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Copy number polymorphisms are not a common feature of innate immune genes Copy number polymorphisms are not a common feature of innate immune genes](/preview/png/2821427.png)
Extensive copy number polymorphism was recently reported for innate immunity-related α-defensin genes DEFA1 and DEFA3 and β-defensin genes DEFB4, DEFB103, and DEFB104. To establish whether such polymorphisms are a common feature of innate immune genes we used quantitative real-time PCR to determine the copy numbers of seven genes whose products have important innate immune functions. The genes encoding lysozyme, lactoferrin, cathelicidin antimicrobial peptide (hCAP18/LL-37), cathepsin G, bactericidal/permeability-increasing protein, azurocidin (CAP37/heparin-binding protein), and neutrophil elastase were each found to be single copy per haploid genome. These findings, along with the recent observation that defensin genes DEFA4, DEFA5, DEFA6, and DEFB1 are single copy, suggest that copy number polymorphisms are not a common feature of the innate immune genome but are restricted to a small subset of innate immunity-related genes.
Journal: Genomics - Volume 88, Issue 1, July 2006, Pages 122–126