کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2821708 1160991 2007 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The sarcomeric myosin heavy chain gene family in the dog: Analysis of isoform diversity and comparison with other mammalian species
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
The sarcomeric myosin heavy chain gene family in the dog: Analysis of isoform diversity and comparison with other mammalian species
چکیده انگلیسی

Sarcomeric myosin heavy chains (MyHC) are the major contractile proteins of cardiac and skeletal muscles and belong to class II MyHC. In this study the sequences of nine sarcomeric MyHC isoforms were obtained by combining assembled contigs of the dog genome draft available in the NCBI database. With this information available the dog becomes the second species, after human, for which the sequences of all members of the sarcomeric MyHC gene family are identified. The newly determined sequences of canine MyHC isoforms were aligned with their orthologs in mammals, forming a set of 38 isoforms, to search for the molecular features that determine the structural and functional specificity of each type of isoform. In this way the structural motifs that allow identification of each isoform and are likely determinants of functional properties were identified in six specific regions (surface loop 1, loop 2, loop 3, converter, MLC binding region, and S2 proximal segment).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Genomics - Volume 89, Issue 2, February 2007, Pages 224–236
نویسندگان
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