کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2821774 1161008 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An initial genetic linkage map of the rhesus macaque (Macaca mulatta) genome using human microsatellite loci
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
An initial genetic linkage map of the rhesus macaque (Macaca mulatta) genome using human microsatellite loci
چکیده انگلیسی

Rhesus macaques (Macaca mulatta) are the most widely used nonhuman primate species in biomedical research. To create new opportunities for genetic and genomic studies using rhesus monkeys, we constructed a genetic linkage map of the rhesus genome. This map consists of 241 microsatellite loci, all previously mapped in the human genome. These polymorphisms were genotyped in five pedigrees of rhesus monkeys totaling 865 animals. The resulting linkage map covers 2048 cM including all 20 rhesus autosomes, with average spacing between markers of 9.3 cM. Average heterozygosity among those markers is 0.73. This linkage map provides new comparative information concerning locus order and interlocus distances in humans and rhesus monkeys. The map will facilitate whole-genome linkage screens to locate quantitative trait loci (QTLs) that influence individual variation in phenotypic traits related to basic primate anatomy, physiology, and behavior, as well as QTLs relevant to risk factors for human disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Genomics - Volume 87, Issue 1, January 2006, Pages 30–38
نویسندگان
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