کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2822631 1161303 2011 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Origin of Patterning Systems in Bilateria—Insights from the Hox and ParaHox Genes in Acoelomorpha
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
The Origin of Patterning Systems in Bilateria—Insights from the Hox and ParaHox Genes in Acoelomorpha
چکیده انگلیسی

Hox and ParaHox genes constitute two families of developmental regulators that pattern the Anterior–Posterior body axis in all bilaterians. The members of these two groups of genes are usually arranged in genomic clusters and work in a coordinated fashion, both in space and in time. While the mechanistic aspects of their action are relatively well known, it is still unclear how these systems evolved. For instance, we still need a proper model of how the Hox and ParaHox clusters were assembled over time. This problem is due to the shortage of information on gene complements for many taxa (mainly basal metazoans) and the lack of a consensus phylogenetic model of animal relationships to which we can relate our new findings. Recently, several studies have shown that the Acoelomorpha most probably represent the first offshoot of the Bilateria. This finding has prompted us, and others, to study the Hox and ParaHox complements in these animals, as well as their activity during development. In this review, we analyze how the current knowledge of Hox and ParaHox genes in the Acoelomorpha is shaping our view of bilaterian evolution.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Genomics, Proteomics & Bioinformatics - Volume 9, Issue 3, June 2011, Pages 65–76
نویسندگان
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