Olfactory dysfunction in Multiple Sclerosis: A scoping review of the literature

• Olfactory dysfunction can be frequently measured in MS patients.
• Both threshold and identification deficits can be observed.
• Correlations between olfactory dysfunction and cognitive dysfunction and depression/anxiety have been observed.
• Olfactory dysfunction in MS correlates with disability as measured by the EDSS.
• Measurements of olfactory dysfunction may wax and wane with relapses.

ObjectiveOlfactory dysfunction in Multiple Sclerosis (MS) has been reported, but results have been inconsistent. In this review we describe, synthesize, and interpret the existing literature on olfactory dysfunction in Multiple Sclerosis and identify gaps in the current level of knowledge.MethodsThe study design was a scoping review of the literature covering several study designs. Systematic Searches of the PubMed, CINAHL, Cochrane Library, Web of Science, PsycARTICLES, PsycINFO and Google Scholar databases were conducted that included key words related to Multiple Sclerosis and Olfaction Disorders. Literature that met the criteria of pertaining to both Multiple Sclerosis and olfactory dysfunction was identified, with the aim of providing an overview of the extent and types of research available in this area.ResultsSixty-one reports were identified in the initial search, with 40 meeting the study criteria. Twenty-five clinical studies were included. Among them, 23 studies measured for olfactory dysfunction in MS patients, ten evaluated MRI correlates of olfactory dysfunction, and five evaluated neurophysiology correlates of olfactory dysfunction. Six of the included studies were abstracts. In addition, thirteen reviews/commentaries and two case studies were included. The majority of the studies identified some degree of olfactory dysfunction in MS patients, and various aspects and correlations with olfactory impairment were observed.ConclusionsThe overall weight of the literature suggests that olfactory dysfunction may occur in MS. Although there is variability in reported frequency, the more robust studies suggest the prevalence is significant, ranging from 20% to 45% in the MS population. Despite this, the mechanisms are unknown and the clinical relevance of this association has not been well explored. Interesting findings relating mood disorders, cognition, and olfactory dysfunction in MS are also suggested but remain poorly developed and require further investigation. Future studies are also warranted to understand the dynamic changes in olfactory function during the course of MS, and to correlate olfactory function with relapses/disease activity.