کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2824875 1161876 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role of AUTS2 in neurodevelopment and human evolution
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
The role of AUTS2 in neurodevelopment and human evolution
چکیده انگلیسی

The autism susceptibility candidate 2 (AUTS2) gene is associated with multiple neurological diseases, including autism, and has been implicated as an important gene in human-specific evolution. Recent functional analysis of this gene has revealed a potential role in neuronal development. Here, we review the literature regarding AUTS2, including its discovery, expression, association with autism and other neurological and non-neurological traits, implication in human evolution, function, regulation, and genetic pathways. Through progress in clinical genomic analysis, the medical importance of this gene is becoming more apparent, as highlighted in this review, but more work needs to be done to discover the precise function and the genetic pathways associated with AUTS2.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 29, Issue 10, October 2013, Pages 600–608
نویسندگان
, ,