کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2825344 1161932 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Copy-number variants in neurodevelopmental disorders: promises and challenges
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Copy-number variants in neurodevelopmental disorders: promises and challenges
چکیده انگلیسی

Copy-number variation (CNV) is the most prevalent type of structural variation in the human genome. There is emerging evidence that copy-number variants (CNVs) provide a new vista on understanding susceptibility to neuropsychiatric disorders. Some challenges in the interpretation of current CNV studies include the use of overlapping samples, differing phenotypic definitions, an absence of population norms for CNVs and a lack of consensus in methods for CNV detection and analysis. Here, we review current CNV association study methods and results in autism spectrum disorders (ASD) and schizophrenia, and provide suggestions for design approaches to future studies that might maximize the translation of this work to etiological understanding.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 25, Issue 12, December 2009, Pages 536–544
نویسندگان
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