کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2825353 1161934 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mystery of intron gain: new data and new models
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Mystery of intron gain: new data and new models
چکیده انگلیسی

Despite their ubiquity, the mechanisms and evolutionary forces responsible for the origins of spliceosomal introns remain mysterious. Recent molecular evidence supports the idea that intronic RNAs can reverse splice into RNA transcripts, a crucial step for an influential model of intron gain. However, a paradox attends this model because the rate of intron gain is expected to be orders of magnitude lower than the rate of intron loss in general, in contrast to findings from several lineages. We suggest two possible resolutions to this paradox, based on steric considerations and on the possibility of co-option by specific introns of retroelement transposition pathways, respectively. In addition, we introduce two potential mechanisms for intron creation, based on hybrid RNA–DNA reverse splicing and on template switching errors by reverse transcriptase.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 25, Issue 2, February 2009, Pages 67–73
نویسندگان
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