کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2825398 1161939 2008 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oncogenes on my mind: ERK and MTOR signaling in cognitive diseases
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Oncogenes on my mind: ERK and MTOR signaling in cognitive diseases
چکیده انگلیسی

Defects in rat sarcoma viral oncogene homolog (RAS)–extracellular signal regulated kinase (ERK) and phosphatidylinositol 3-kinase (PI3K)–mammalian target of rapamycin (MTOR) signaling pathways have recently been shown to cause several genetic disorders classified as neuro-cardio-facial-cutaneous (NCFC) and Hamartoma syndromes. Although these pathways are well-known players in cell proliferation and cancer, their role in cognitive function is less appreciated. Here, we focus on the cognitive problems associated with mutations in the RAS–ERK and PI3K–MTOR signaling pathways and on the underlying mechanisms revealed by recent animal studies. Cancer drugs have been shown to reverse the cognitive deficits in mouse models of NCFC and Hamartoma syndromes, raising hopes for clinical trials.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 24, Issue 10, October 2008, Pages 498–510
نویسندگان
, , ,