Signals from chloroplasts and mitochondria for iron homeostasis regulation

Iron (Fe) is an essential element for human nutrition. Given that plants represent a major dietary source of Fe worldwide, it is crucial to understand plant Fe homeostasis fully. A major breakthrough in the understanding of Fe sensing and signaling was the identification of several transcription factor cascades regulating Fe homeostasis. However, the mechanisms of activation of these cascades still remain to be elucidated. In this opinion, we focus on the possible roles of mitochondria and chloroplasts as cellular Fe sensing and signaling sites, offering a new perspective on the integrated regulation of Fe homeostasis and its interplay with cellular metabolism.

► The understanding of plant iron homeostasis must be fully elucidated.
► We review the knowledge of metabolic adaptation in response to altered iron availability.
► Mitochondria and chloroplasts are proposed to act as cellular iron sensing and signaling sites.