کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2894965 1172446 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Myeloperoxidase genetic polymorphisms modulate human neutrophil enzyme activity: Genetic determinants for atherosclerosis?
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Myeloperoxidase genetic polymorphisms modulate human neutrophil enzyme activity: Genetic determinants for atherosclerosis?
چکیده انگلیسی

ObjectiveMyeloperoxidase (MPO), an abundant leukocyte hemoprotein has been linked to atherosclerosis and cardiovascular disease. We previously found new genetic polymorphisms in MPO gene. The purpose of this study was to evaluate the influences of these polymorphisms on human neutrophil MPO activity by means of haplotype analysis.Methods and resultsNeutrophils from 102 blood donors were isolated and MPO activity was measured, while subjects were genotyped for polymorphisms located in MPO gene 5′non-coding region (−1940A > G, −638C > A, −463G > A and −129G > A) and in coding region (V53F, M251T, A332V, I642L and I717V). Single-point analysis showed that the −638C > A and the V53F polymorphisms were significantly associated with MPO activity, and haplotype analysis confirmed that two haplotypes, one carrying the −638A allele and the other carrying the 53F allele, resulted an increase in MPO activity.ConclusionSince MPO is suspected to be a bio-marker in cardiovascular disease, −638C > A and V53F polymorphisms associated with increased enzymatic activity could be genetic determinants for cardiovascular disease risk.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 188, Issue 1, September 2006, Pages 150–154
نویسندگان
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